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In January 2022, the average price of domestic titanium dioxide in local Chinese marketplaces was 20,735 RMB/MT. Traders were more careful in purchasing goods and downstream industries purchased things on demand. As a result, the overall market demand for titanium dioxide was general.

A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO₂. However, these same effects were not seen when the same or higher doses of food-grade TiO₂ were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO₂ from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.