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Offers good thermal stability, which makes it useful in high-temperature applications

HPMC capsules incorporate a gelling agent to achieve enteric properties, allowing for the protection of sensitive ingredients from the acidic environment of the stomach and complete dissolution in the intestine. They also provide sufficient taste-masking and acid-resistance to prevent gastric reflux for fish oils and have become the solution of choice for numerous probiotics, herbal or mineral formulations on the market today.

Environmental Considerations

One of the key features of HMPC is its solubility in both hot and cold water, which makes it particularly useful in diverse applications. When dissolved, it forms a clear, viscous solution that can easily be tailored in viscosity by varying the concentration of HMPC. The presence of hydroxy groups (–OH) in its structure allows HMPC to form hydrogen bonds with water molecules, enhancing its water-retention capabilities and making it an effective thickening agent. Furthermore, HMPC exhibits exceptional stability across a wide range of pH conditions, making it suitable for neutral to alkaline environments.

Following neutralization, the hydroxyethyl cellulose is typically precipitated from the solution. This can be done by adding a non-solvent (often alcohol or other organic solvents), causing the HEC to aggregate and settle out of the solution.