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EFSA's evaluation is related to the risks of TiO₂ used as a food additive, not to other uses.

In Europe, the downstream paints and coatings sector presented weak demand in front of the titanium dioxide manufacturers, and thus, the titanium dioxide price trend experienced a gradual decline in its trajectory. Additionally, the pressure of inflation and increasing bank interest rates lowered the spending appetite of consumers which had an adverse effect on the titanium dioxide price trends. Further, the export and import of titanium dioxide were also caught under the negative influence of the poor economic conditions of the market.

Yet another study, this one published in 2006 by the International Agency for Research on Cancer said there was insufficient evidence to conclude that titanium dioxide causes cancer. However, the study also categorized the ingredient as a potential human carcinogen.