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But, there are some potential disadvantages that are not immediately obvious. HPMC is listed as a food ingredient — E464 — which means that recommended daily maximum quantities must be defined. HPMC undergoes a rigorous manufacturing process involving the synthetic — and not natural — alteration of cellulose. During production, various highly reactive, harmful or toxic substances are used that must be removed and disposed after production, including propylene oxide (which is considered to be carcinogenic) and chloromethane.