Moreover, the FEEDAP Panel also noted that methyl cellulose and carboxymethyl cellulose have been used for a long time as vehicles for non-water-soluble substances in several in vivo genotoxicity assays and are recommended for this use by the current OECD test guidelines (e.g. TGs 474, 475, 478 and 483). Based on the available experimental data, neither microcrystalline cellulose nor modified cellulose (including HPMC) raise concern for genotoxicity.