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1)Hydroxypropyl Methylcellulose is soluble in cold water, while dissolution in hot water can be challenging. However, its gelation temperature in hot water is significantly higher than that of Methyl Cellulose. Compared to Methyl Cellulose, Hydroxypropyl Methylcellulose shows improved solubility in cold water.

Hydroxypropyl methylcellulose (HPMC) is considered safe for use in supplements based on extensive regulatory approvals and toxicology studies. It has been shown to have low toxicity, with no evidence of genotoxicity or carcinogenicity in animal studies. Although some people may experience mild gastrointestinal side effects, these are usually short-lived and not serious. However, as with any supplement, products containing HPMC must be used as directed and consult a healthcare professional if you have any concerns or underlying medical conditions. Overall, if used appropriately, HPMC can be a safe and effective ingredient in dietary supplements.