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The FDA has not updated its general guidance on safety assessments since 2007. Within that time, there has been a significant increase in research on the confluence of toxicology, nanotechnology and human health. The EU updates its guidance regularly with new science available to offer proper safety assessments, with its most recent update published in 2021.

Overall, the Food Directorate's comprehensive review of the available science of TiO₂ as a food additive showed:

EFSA’s scientific advice will be used by risk managers (the European Commission, Member States) to inform any decisions they take on possible regulatory actions.

Anatase titanium dioxide is a popular ingredient in coatings due to its excellent UV resistance and chemical stability. Many manufacturers and businesses rely on wholesale suppliers to provide high-quality anatase titanium dioxide for their coating applications.