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Polyphenols, such as curcumin, have gained popularity because epidemiological studies have repeatedly shown that diets rich in them can provide inflammatory relief. At the molecular level, polyphenols help stabilize oxidation in cellular components. Oxidation can lead to damage to organelles within cells, including mitochondria, the cell powerhouses where much of the cell's energy is produced by the oxygen we breathe. Eating foods with antioxidant properties, such as berries, nuts, healthy fats, and turmeric, is thought to help maintain levels of oxidative damage.

In order to generate this chain of chemical reactions, signaling molecules are produced and released by the cell, leading to more inflammatory responses and a continuous cycle of cells and molecules, meaning that the inflammatory response becomes more severe. Many studies have shown that curcumin blocks these cellular signals, thus helping to maintain the number of inflammatory response proteins and cells. However, in many of these studies, researchers have found that curcumin has poor bioavailability.