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Is titanium dioxide dangerous? Has it been linked to any health issues?

In the experiment, the growth of iron yellow particles can be inhibited by adding additives, so as to prepare iron oxide yellow cryst

Available studies in humans and postmortem analysis of tissues suggested that the oral bioavailability of titanium dioxide in humans is very low. JECFA noted that there are currently no epidemiological studies that allow any conclusions to be drawn with respect to an association between dietary exposure titanium dioxide and human health effects.