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Titanium Dioxide is largely produced by the reduction of titanium tetrachloride, obtained in turn from chlorination of natural rutile, synthetic rutile derived from ilmenite or even slags rich in TiO2 produced by metallurgical treatment of ilmenite. TiO2 is also manufactured by treatment of ilmenite with sulfuric acid. Raw materials and the respective production processes employed in the manufacturing of Titanium Dioxide are listed below.

Titanium dioxide as used in sunscreens is commonly modified with other ingredients to ensure efficacy and stability. Examples of what are known as surface modifier ingredients used for titanium dioxide include stearic acid, isostearic acid, polyhydroxystearic acid, and dimethicone/methicone copolymer.