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In a 2022 study published in the Journal of Hazardous Materials, scientists wanted to examine the effects of titanium dioxide as a food additive on atherosclerosis in mice. (Atherosclerosis refers to a hardening of the arteries.) Researchers fed mice 40 mg/kg of the food additive every day for 4 months, and found that it not only altered gut microbiota but also led to a significantly increased atherosclerotic lesion area, especially in animals that consumed a high-choline western diet (HCD).

4. Cost-Effectiveness Purchasing titanium dioxide in wholesale quantities can lead to significant cost savings for tire manufacturers. By acquiring TiO2 in bulk, manufacturers can reduce production costs per unit, thereby improving their profit margins. Moreover, the durability and performance enhancements associated with TiO2 help reduce the frequency of tire replacements, further amplifying cost efficiency.