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Concerning modified celluloses, methyl cellulose was negative in the bacterial reverse mutation assay, in the in vitro chromosomal aberration test in mammalian cells and in host-mediated assays with yeast and bacteria. In vivo methyl cellulose was also negative in a chromosome aberration assay in rat bone marrow and in the dominant lethal assay in male rats. Carboxymethyl cellulose was negative in the bacterial reverse mutation assay, in the in vitro chromosomal aberration test in mammalian cells, performed only without metabolic activation, and in host-mediated assays.

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