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Titanium dioxide used for adhesive applications should contain an inorganic coating to control polarity, improve its ease of dispersion, and improve its weather resistance. The inorganic coating (zirconium dioxide, silica, alumina) is applied in the aqueous slurry by precipitation of one or more hydrated metal oxides and by neutralization of acidic and alkaline compounds.

Following the EU’s ban on E171, the FDA told the Guardian that, based on current evidence, titanium dioxide as a food additive is safe.  “The available safety studies do not demonstrate safety concerns connected to the use of titanium dioxide as a color additive.”