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When used in an OTC drug product Hydroxypropyl Methylcellulose must be called Hypromellose. The safety of Cellulose, Calcium Carboxymethyl Cellulose, Carboxymethyl Cellulose Acetate Butyrate, Carboxymethyl Hydroxyethylcellulose, Cellulose Acetate, Cellulose Acetate Butyrate, Cellulose Gum, Cellulose Acetate Propionate, Cellulose Acetate Propionate Carboxylate, Cellulose Succinate, Cetyl Hydroxyethylcellulose, Ethylcellulose, Hydrolyzed Cellulose Gum, Hydroxybutyl Methylcellulose, Hydroxyethylcellulose, Hydroxyethyl Ethylcellulose, Hydroxypropylcellulose, Hydroxypropyl Methylcellulose, Methylcellulose, Hydroxypropyl Methylcellulose Acetate/Succinate, Methylcellulose, Methyl Ethylcellulose, Methyl Hydroxyethylcellulose, Microcrystalline Cellulose, Potassium Cellulose Succinate and Sodium Cellulose Sulfate has been assessed by the Cosmetic Ingredient Review (CIR) Expert Panel. The CIR Expert Panel evaluated the scientific data and concluded that these ingredients were safe as cosmetic ingredients.

In the food industry, HPMC is used as a thickening and gelling agent in a wide range of products, including soups, sauces, and desserts. Its water solubility allows for easy dispersion and hydration, resulting in a smooth and stable texture. HPMC is also used as a fat replacer in low-fat or reduced-calorie products, providing the desired mouthfeel without the added calories.

2. Degree of Substitution (DS) This refers to the number of hydroxyl groups replaced by hydroxypropyl and methyl groups. A higher DS usually leads to greater water solubility and viscosity. Choosing the right DS is essential to achieving the desired release rate and bioavailability of the drug.