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There is also some evidence to suggest that exposure to titanium dioxide nanoparticles may be harmful or toxic to the environment, including aquatic life and other organisms. The production and disposal of the mineral may also release pollutants, such as carbon dioxide and sulfur dioxide, into the air and water.

Titanium dioxide nanoparticles have also been found in human placentae and in infant meconium, indicating its ability to be transferred from mother to fetus.