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A number of toxicological studies have been conducted to evaluate the safety of HPMC. These studies include acute, subchronic and chronic toxicity assessments, as well as genotoxicity and carcinogenicity studies. Overall, these findings suggest that HPMC is safe when consumed within the recommended dosage range.

1)The water retention of Methyl Cellulose depends on the dosage, viscosity, particle size, and dissolution rate. Generally, higher dosage, smaller particle size, and higher viscosity result in better water retention. Among various cellulose ethers, Methyl Cellulose and Hydroxypropyl Methylcellulose exhibit higher water retention.