A number of toxicological studies have been conducted to evaluate the safety of HPMC. These studies include acute, subchronic and chronic toxicity assessments, as well as genotoxicity and carcinogenicity studies. Overall, these findings suggest that HPMC is safe when consumed within the recommended dosage range.

A proper identification and characterisation of HPMC as required for a feed additive is not available and the occurrence of potential toxic impurities cannot be assessed.