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Titanium dioxide (TiO₂) is considered as an inert and safe material and has been used in many applications for decades. However, with the development of nanotechnologies TiO₂ nanoparticles, with numerous novel and useful properties, are increasingly manufactured and used. Therefore increased human and environmental exposure can be expected, which has put TiO₂ nanoparticles under toxicological scrutiny. Mechanistic toxicological studies show that TiO₂ nanoparticles predominantly cause adverse effects via induction of oxidative stress resulting in cell damage, genotoxicity, inflammation, immune response etc. The extent and type of damage strongly depends on physical and chemical characteristics of TiO₂ nanoparticles, which govern their bioavailability and reactivity. Based on the experimental evidence from animal inhalation studies TiO₂ nanoparticles are classified as “possible carcinogenic to humans” by the International Agency for Research on Cancer and as occupational carcinogen by the National Institute for Occupational Safety and Health. The studies on dermal exposure to TiO₂ nanoparticles, which is in humans substantial through the use of sunscreens, generally indicate negligible transdermal penetration; however data are needed on long-term exposure and potential adverse effects of photo-oxidation products. Although TiO₂ is permitted as an additive (E171) in food and pharmaceutical products we do not have reliable data on its absorption, distribution, excretion and toxicity on oral exposure. TiO₂ may also enter environment, and while it exerts low acute toxicity to aquatic organisms, upon long-term exposure it induces a range of sub-lethal effects.

In recent years, there has been a growing focus on sustainability and environmental responsibility in the manufacturing industry. Titanium dioxide manufacturers are no exception, with many companies implementing eco-friendly practices to minimize their impact on the environment. This includes reducing energy consumption, implementing recycling programs, and exploring alternative production methods that are more environmentally friendly.

In addition to Skittles, other candies that contain titanium dioxide include Nice! mints, Trolli sour gummies and Ring Pops, according to Environmental Working Group. 

Store in a cool, ventilated, dry warehouse. Should pay attention to heat and moisture. Store separately from acid products. Lightly load and unload during handling to prevent damage to the packaging. Packed in woven bags lined with polyethylene plastic bags, each bag has a net weight of 25kg. In case of fire, use water and various fire extinguishers to save.