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A  2023 study published in the journal Environmental Research, scientists examined the effect of titanium dioxide nanoparticles on important gut bacteria in mice. Their results showed “the growth inhibitory effects could be associated with cell membrane damage caused by titanium dioxide nanoparticles to the bacterial strains. Metabolomics analysis showed that TiO2 NPs caused alterations in multiple metabolic pathways of gut bacteria, such as tryptophan and arginine metabolism, which were demonstrated to play crucial roles in regulating gut and host health.” The researchers also found that four different neuroprotective metabolites “were significantly reduced” in urine and in vitro bacteria and vivo urine samples. The researchers concluded: “Increasing evidence implies that the gut microbiome plays a profound role in regulating host metabolism. Our results illustrated that TiO2 NPs hindered the growth of four beneficial gut bacterial strains.”

Calcium carbonate (CaCO3) and titanium dioxide (TiO2) are two widely used industrial materials with various applications. In this article, we will discuss the importance of CaCO3 and TiO2 in manufacturing processes and their impact on the global economy.

Fig. 9. Selected images of damaged skin treated with P25TiO₂NPs 10% (left) and healthy skin treated with VitaminB2@P25TiO₂NPs 10% (right).

Overall, the Food Directorate's comprehensive review of the available science of TiO₂ as a food additive showed: