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A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO₂. However, these same effects were not seen when the same or higher doses of food-grade TiO₂ were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO₂ from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.

The use of titanium dioxide (TiO2) in factory settings is widespread, with this versatile compound playing a crucial role in various industrial processes. TiO2 is a naturally occurring mineral that is widely used as a white pigment in paints, coatings, plastics, paper, and other products. Its ability to effectively scatter light makes it an ideal choice for creating bright, durable, and long-lasting finishes.

Molecular weight: 412.23