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1. Pharmaceuticals In the pharmaceutical sector, HPMC serves as a controlled-release agent, ensuring the gradual release of active ingredients in formulations. It is also used as a binder in tablet formulation, helping to improve the mechanical strength of tablets while maintaining disintegration criteria.
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Once the cellulose is purified, it undergoes a series of chemical modifications to produce HPMC. The first step involves treating cellulose with an alkaline substance, such as sodium hydroxide. This treatment swells the cellulose fibers and makes them more reactive. Following this, propylene oxide and methyl chloride are introduced to the cellulose under specific temperature and pressure conditions. These reagents interact with the cellulose to introduce hydroxypropyl and methoxy groups onto the cellulose chain, effectively transforming it into HPMC.
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