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As a food additive, titanium dioxide and its nanoparticles in particular have been associated with DNA damage and cell mutations, which in turn, have potential to cause cancer. When used as a food coloring, it is known as E171.

Understanding Gravimetric Analysis

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However, it’s also important to note that such adverse effects depend heavily on the form of the titanium dioxide. It can come down to characteristics like “particle shape, purity, surface charge, solubility, agglomeration rate, photo-activation, etc.”

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When E171 isn’t combined with other ingredients and administered in water, some studies suggest that under these artificial conditions, E171 may be processed differently in the body resulting in some biological changes in experimental animals that are poorly understood.