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“Regular” paprika, also called American, sweet, basic, or Domestic Paprika, is what’s found in most grocery stores. It is gentle and earthy with an unassertive flavor. Regular paprika is never smoked. It makes a terrific backdrop for more strongly-flavored ingredients, so it’s often used as a flavor base in dry rubs or blends. It is often favored for its ability to deliver a bold, red color. 

Answer: No, they’re not directly interchangeable. When comparing paprika to crushed red pepper, it’s important to know that these two spices differ significantly in flavor and heat. Paprika, often made from sweeter peppers, provides color and a mild taste without much heat. Crushed red pepper, made from hotter peppers and seeds, offers a spicy kick. Substituting one for the other can change your dish’s flavor and spice level significantly, as paprika is milder and more about flavor, while crushed red pepper is all about adding heat.

If you wonder whether you can substitute one for the other, the answer is yes. You would use a lot less red chili powder, even if it is of the milder variety, than you would paprika. In fact, the best way to go about this is add it slowly and in small amounts, till you get the heat factor that you want. In a pinch, you can use paprika instead of red chili powder as well, though you may not get the color that you want and the flavor may be different.