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In the realm of pharmaceuticals, the choice of excipients plays a crucial role in determining the functionality and efficacy of drug formulations. Among various excipients available, Hydroxyethyl Cellulose (HEC) and Hydroxypropyl Methylcellulose (HPMC) are two widely utilized materials known for their thickening, emulsifying, and binding properties. While they share similar characteristics, their distinct chemical structures and physical properties can lead to different functionalities in pharmaceutical applications. This article aims to compare HEC and HPMC, highlighting their unique attributes, uses, and implications in drug delivery systems.