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The uses and applications of Titanium Dioxide may vary according to its specification. The main forms of Titanium Dioxide are dependent on particle sizes, surface treatment, and crystalline forms.

When used in food specifically, titanium dioxide is known as an additive called E171 and can be found in products like candy, chocolate, coffee creamer, cake decorations, chewing gum and even vitamin supplements. E171 is often used as coloring additive in foods, to lend the processed item a natural whiteness and opacity — such as in Skittles candy, where it's used as a white base to help give the candies their signature bright, colorful hue.

The concern from animal studies is that high amounts of titanium dioxide have increased inflammation and colon tumor formation, said Dr. Johnson-Arbor. A 2021 review, meanwhile, suggested that using titanium dioxide as a food additive weakens the gut lining and worsens the progression of inflammatory bowel disease.

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With its storied history and distinct properties, lithopone remains a subject of historical significance and contemporary relevance. While its applications and popularity have evolved, its role in the annals of pigment history is indisputable.