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Following a request for assessment in 2020 by the EU, the European Food Safety Authority (EFSA) assessed E171, particularly for its genotoxicity. In 2022, the agency deemed the food additive no longer safe for use.  

A safety review conducted by the EFSA in 2021 assessed thousands of studies published on titanium dioxide.

The paints & coatings segment contributed the largest in the global Lithopone market share. It is added to paint as a white pigment to enhance its surface properties such as UV resistance and resistance to fungicidal and algae growth. 

In a small study published in the European Journal of Nutrition in 2020, researchers examined the effects of several food additives, including titanium dioxide, along with artificial sweeteners and cleaning products by testing the fecal samples of 13 people. Titanium dioxide was among the samples that “induced significant shifts in microbiome community structure.”  The growth of the bacterium species belonging to C. leptum, which has been shown to decrease in patients with inflammatory bowel disease, “significantly decreased in the presence of … titanium dioxide” among other additives and sweeteners tested.

In terms of refractive index and opacity, lithopone surpasses zinc oxide and lead oxide. Lithopone's high refractive index allows it to efficiently scatter and reflect light, thereby increasing the opacity of various media. Whether you need to enhance the opacity of paints, inks or plastics, lithopones deliver outstanding results, ensuring your final product is completely opaque.