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HPMC is a derivative of cellulose, a natural polymer found in plant cell walls. It is synthesized by the hydroxypropylation and methylation of cellulose. This process endows HPMC with excellent water solubility, film-forming capabilities, and thickening properties, making it an ideal additive in many formulations.
HPMC's solubility is another important aspect to consider. It is water-soluble and forms a gel upon heating, making it a popular choice for hot and cold processes. The degree of hydroxypropyl and methoxy substitution, which defines the grades of HPMC, dictates its solubility and viscosity. For instance, HPMC with a higher degree of hydroxypropyl substitution tends to have greater solubility in cold water, leading to a smoother dispersion and a more consistent viscosity profile. This characteristic makes it suitable for pharmaceutical applications, such as in tablet production, where uniformity is essential.
hpmc grades viscosity

2. Medium-Viscosity HPMC With viscosities ranging from 5,000 to 15,000 mPa·s, this grade is a popular choice for various applications, including pharmaceutical formulations and personal care products. In the pharmaceutical industry, medium-viscosity HPMC is often used as a binder in tablet formulations, providing adequate flow and cohesion during the manufacturing process.
different grades of hpmc
