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In some studies, E171 was given to animals in drinking water without the stabilizers that keep E171 suspended in the liquid. Without stabilizers, E171 can settle and prevent the ingredient from combining with surrounding ingredients.

Titanium dioxide is a naturally-occurring mineral found in the earth’s crust. Because of its white color, opaqueness, and ability to refract light, the ingredient is often used as a pigment, brightener, and opacifier, which is an ingredient that makes a formulation more opaque. Titanium dioxide is also a UV filter and so is an effective active ingredient in sunscreens. It’s often used in cosmetic loose and pressed powders, especially “mineral powder” cosmetics, in addition to other cosmetics, lotions, toothpaste, and soap.

It's also used in sunscreens as a UV filtering ingredient, helping to protect a person's skin by blocking absorption the ultraviolet light that can cause sunburn and cancer.