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In a 2022 study published in the Journal of Hazardous Materials, scientists wanted to examine the effects of titanium dioxide as a food additive on atherosclerosis in mice. (Atherosclerosis refers to a hardening of the arteries.) Researchers fed mice 40 mg/kg of the food additive every day for 4 months, and found that it not only altered gut microbiota but also led to a significantly increased atherosclerotic lesion area, especially in animals that consumed a high-choline western diet (HCD).

It is recommended to store Titanium Dioxide in a well-maintained and dry environment, safeguarding it from exposure to elevated temperatures, open flames, or aromatic chemicals. When transporting Titanium Dioxide pigments, they are commonly packaged in paper bags weighing 25 kg (50 lb) or in large bags constructed from woven polypropylene materials.

Alterations in gut microbiota