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CIR Safety Review: Sorbic Acid and Potassium Sorbate were practically nontoxic in acute oral toxicity studies. In subchronic studies, no significant adverse effects were observed when 10% Sorbic Acid was included in the diet. Sorbic Acid and Potassium Sorbate, at concentrations up to 10%, were practically nonirritating to the eye. Both ingredients at concentrations up to 10% were at most only slightly irritating to skin. Sorbic Acid and Potassium Sorbate have been tested for mutagenic effects using bacterial tests, genetic recombination tests, reversion assays, tests for chromosomal aberrations, sister chromatid exchanges and gene mutations. The weight of evidence of these tests indicates that these ingredients were not mutagenic. Potassium Sorbate at 0.1% in the diet or 0.3% in drinking water for up to 100 weeks was not carcinogenic. In other chronic studies, no carcinogenic effect was demonstrated by Sorbic Acid in diets containing up to 10% Sorbic Acid. No developmental effects have been observed with Potassium Sorbate. Formulations containing up to 0.5% Sorbic Acid and or Potassium Sorbate were not significant primary or cumulative irritants and not sensitizers.