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A few non-dietary studies have reported adverse effects in the gastrointestinal tract of laboratory animals given food-grade TiO₂. However, these same effects were not seen when the same or higher doses of food-grade TiO₂ were administered in the animals' diet. Dietary studies best reflect how humans are exposed to TiO₂ from food. Thus, the Food Directorate placed the most emphasis on the results of these studies in the state of the science report.

The European Commission banned titanium dioxide as a food additive in the EU in 2022 after the European Food Safety Authority (EFSA) conducted an updated safety assessment of E171 and concluded the panel could not eliminate concerns about its genotoxicity. 

R-5566:

When looking for suppliers of r 996 titanium dioxide, it is important to consider a few key factors. First and foremost, the quality of the product is paramount. r 996 titanium dioxide suppliers are known for their high-quality products that meet industry standards and specifications. This ensures that the end products manufactured using this pigment are of top-notch quality.

Currently, titanium dioxide as a food additive is classified as GRAS, or “generally recognized as safe.”