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The most significant uncertainty identified by the EU experts was the concern that TiO₂ particles may have genotoxic effects. Genotoxicity refers to the ability of a chemical to directly damage genetic material within a cell (DNA), which may lead to cancer in certain situations. Although the experts did not conclude that TiO₂ particles in E171 are genotoxic, they could not rule out the concern that they might be.

Overall, titanium dioxide manufacturers play a crucial role in supplying this essential compound to industries around the world. By focusing on quality, sustainability, and innovation, manufacturers can ensure a stable supply of titanium dioxide for years to come.