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After conducting a review of all the relevant available scientific evidence, EFSA concluded that a concern for genotoxicity of TiO₂ particles cannot be ruled out. Based on this concern, EFSA’s experts no longer consider titanium dioxide safe when used as a food additive. This means that an Acceptable Daily Intake (ADI ) cannot be established for E171.

But this is just the tip of the ice berg so many articles & studies are coming out challenging the safety of Titanium Dioxide in our food supply & personal care products.