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The methylation process involves the substitution of hydroxyl (-OH) groups on the cellulose chain with methyl (-OCH₃) groups, which enhances the hydrophobic characteristics of the polymer. This substitution plays a critical role in determining the solubility and viscosity of HPMC in various solvents. The degree of substitution, which refers to the average number of hydroxyl groups replaced by methyl groups, greatly influences the properties of HPMC, such as its thickening ability and gel formation capacity.
chemical structure of hpmc

3. Thickening and Stabilizing Agent HPMC serves as an effective thickening agent in liquid formulations, creating a desirable viscosity that enhances the texture and mouthfeel of the product. Additionally, it helps stabilize emulsions, preventing the separation of oil and water phases, which is crucial for maintaining the quality of liquid supplements.
hydroxypropyl methyl cellulose in supplements
