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Above 20%, it is recommended to replace 1 kg TiO2 with 1.3 kg of Lithopone 30%.  

After oral ingestion, the absorption of titanium dioxide particles is low, however they can accumulate in the body, Maged Younes, chair of the European Food Safety Authority's expert Panel on Food Additives and Flavourings, said in a May 2021 statement.

Titanium dioxide (TiO2) is a fine white powder or dust that occurs naturally. It was first intentionally produced for use as a white pigment in 1923.