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In 2017, French researchers from the Institut National de la Recherche Agronomique (INRAE) were among the first to examine the effects of E171 nanoparticles on the body. They fed rats a dose of 10mg of E171 per kilogram of body weight per day, which was similar to human exposure in food. The research, which was published in Scientific Reports, showed that E171 was able to traverse the intestinal barrier, pass into the bloodstream, and reach other areas of the body in rats. Researchers also found a link between immune system disorders and the absorption of titanium dioxide nanoparticles. 

In conclusion, lithopone is an important white pigment that is used in a variety of industries around the world. With 30% of the world's lithopone factories located in China, the country has become a major player in the global lithopone market. Chinese manufacturers are able to produce high-quality lithopone at a competitive price, making it an attractive option for companies looking to reduce their production costs. Despite the challenges of production, China's lithium industry continues to thrive and innovate, ensuring a stable and reliable supply of this essential pigment for years to come.

In its statement to USA TODAY, the FDA maintained that, in all post-approvals for food additives, our scientists continue to review relevant new information to determine whether there are safety questions and whether the use of such substance is no longer safe under the Federal Food, Drug, and Cosmetic Act.

Lithopone B301, Lithopone B311 powder is widely used in coatings, printing ink, rubber, plastic industry, etc.