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In order to generate this chain of chemical reactions, signaling molecules are produced and released by the cell, leading to more inflammatory responses and a continuous cycle of cells and molecules, meaning that the inflammatory response becomes more severe. Many studies have shown that curcumin blocks these cellular signals, thus helping to maintain the number of inflammatory response proteins and cells. However, in many of these studies, researchers have found that curcumin has poor bioavailability.

The primary distinction between crushed red pepper and paprika lies in their flavor profiles and heat levels: