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Just like with most things, though, not all cotton plants are created equal. Egyptian cotton that grows along the Nile River produces the highest quality textiles because of its extra-long staples. 

 Thread count is another important factor to consider when choosing flannel sheets.  While the higher the thread count of regular cotton sheets, the better the quality, with flannel sheets, this is less important.  Instead, focus on the fabric weight and overall feel of your bed sheets to gauge their quality.