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So, can you substitute cayenne for paprika (or vice versa)? While you’ll at least end up with a similarly colored dish, the flavor won’t be the same. In a pinch, you could throw in a dash of hot paprika in place of cayenne powder. However, we wouldn’t suggest substituting these spices the other way around—you could wind up with a way-too-spicy sauce!

If you are using a recipe that calls for powdered chili peppers of this kind, you can usually use cayenne pepper substitute without significantly changing the taste of the dish.