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Authors like to thank Sebastián García (LAMARX) for spectra acquisition, Carolina Leimbruguer for her support with TEM images and Yanina Altamirano, Nicolas Jaime and Javier Reparaz for animal care assistance.

The FDA categorized titanium dioxide as “Generally Recognized as Safe,” but there are warnings about its potential dangers from other organizations.

Titanium dioxide used for adhesive applications should contain an inorganic coating to control polarity, improve its ease of dispersion, and improve its weather resistance. The inorganic coating (zirconium dioxide, silica, alumina) is applied in the aqueous slurry by precipitation of one or more hydrated metal oxides and by neutralization of acidic and alkaline compounds.

Lithopone 30% has a lower coverage power than titanium dioxide. For this reason, Lithopone 30% can only partially substitute titanium dioxide, between 5 and 40%.