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Food containing titanium dioxide that is lawfully placed on the EU market before 7 August 2022 may remain on the market until its date of minimum durability or its ‘use-by’ date has passed. Food produced or placed on the market after 7 August 2022 cannot contain titanium dioxide. The ban on the use of titanium dioxide is effective in each EU Member State, and in Northern Ireland. Some third countries, such as the United Kingdom (excluding Northern Ireland), continue to permit the use of titanium dioxide.

A 2022 review on past studies of titanium dioxide and rat lung cancer, for instance, said the original study was under extreme conditions and its effects were not replicated in other animal species. Additionally, the review concluded that the few studies which did directly focus on titanium dioxide's impact on humans did not end up showing any increased cancer risk.