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There is no easy answer to where paprika comes from. While paprika is closely associated with Hungary and Hungarian cuisine, paprika peppers did not arrive in that part of the world until the mid to late 16th century. The origin of all peppers can be traced to South America, where they grew wild and were distributed throughout South and Central America, mostly by birds. Eventually, peppers were cultivated, and native traders travelling through these regions carried them across the Caribbean as cargo in dugout canoes.  

In order to generate this chain of chemical reactions, signaling molecules are produced and released by the cell, leading to more inflammatory responses and a continuous cycle of cells and molecules, meaning that the inflammatory response becomes more severe. Many studies have shown that curcumin blocks these cellular signals, thus helping to maintain the number of inflammatory response proteins and cells. However, in many of these studies, researchers have found that curcumin has poor bioavailability.

I highly advise that you gradually add the powdered or crushed red pepper flakes to your recipe. Start with one-third of a teaspoon for every teaspoon of paprika. Give it a taste to check the heat and spiciness, and add more when needed.