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Based on this opinion, the European Commission and the Member States agreed to remove all uses of titanium dioxide as an additive in food. In January 2022, a Regulation withdrawing the authorisation to use titanium dioxide as a food additive in food products was adopted i.e. Commission Regulation (EU) 2022/63.

How pure TiO2 is extracted from titanium-containing molecules depends on the composition of the original mineral ores or feedstock. Two methods are used to manufacture pure TiO₂: a sulphate process and a chloride process.