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One of the primary concerns associated with HPMC is its potential to cause gastrointestinal distress, particularly when consumed in large quantities. Individuals may experience symptoms such as bloating, gas, abdominal discomfort, and diarrhea. These side effects are generally mild and temporary, often resolving once the intake of HPMC is reduced or eliminated. However, for those with sensitive digestive systems or pre-existing gastrointestinal conditions, even smaller amounts of HPMC may trigger adverse reactions.

In addition to its functional benefits, HPMC also contributes to the flexibility of the mortar. Flexible mortars are essential in applications where movement could occur due to temperature variations or structural dynamics. By incorporating HPMC into mortar, it becomes more resilient and capable of accommodating slight movements, reducing the likelihood of cracks and ensuring that joints remain intact.