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Moreover, the gravimetric method's inherent accuracy makes it a preferred choice for regulatory compliance. Many manufacturing processes are subject to stringent quality regulations, and having reliable methods for determining material composition is fundamental to meeting these standards. Accurate gravimetric analysis assists manufacturers in minimizing waste, optimizing formulations, and ensuring that end products are both effective and safe.

Mexican researchers sought to evaluate the effects of E171 across a span of conditions in mice, including its influence on behavior, along with the effects on the colon and liver. The research, published in 2020 in the journal Food and Chemical Toxicology, showed that E171 promoted anxiety and induced adenomas, or noncancerous tumors, in the colon. They also found that E171 heightened goblet cells hypertrophy and hyperplasia, which is typically seen in asthma patients and triggered by smoking or external pollutants and toxins. They also noted mucins overexpression in the mice, which can be linked to cancer cell formation.