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Yet another study, this one published in 2006 by the International Agency for Research on Cancer said there was insufficient evidence to conclude that titanium dioxide causes cancer. However, the study also categorized the ingredient as a potential human carcinogen.

One of the key challenges facing TiO2 industry suppliers is the fluctuation of raw material prices. The production of TiO2 requires raw materials such as ilmenite or rutile, which are subject to market price volatility. Suppliers must carefully monitor these fluctuations and adjust their production processes accordingly to ensure profitability.