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Because of its unique pigment and fine-milled texture, titanium dioxide has become popular over the past century in a wide variety of different products. These include adhesives, paints, plastics, rubbers, textiles, inks, ceramics, and even some pharmaceuticals, foods, and hygiene products.

In some studies, E171 was given to animals in drinking water without the stabilizers that keep E171 suspended in the liquid. Without stabilizers, E171 can settle and prevent the ingredient from combining with surrounding ingredients.