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They are the only two sunscreen ingredients classified by the FDA as safe and effective. And though titanium dioxide is usually used in mineral sunscreens in the form of nanoparticles, evidence suggests that few, if any, particles penetrate the skin.

As of August 7, the use of titanium dioxide in food is banned in the European Union. Europe is taking a precautionary principle approach based on findings from the European Food Safety Authority (EFSA).