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If you are taking medications, consult your doctor before considering starting curcumin supplements. In vitro studies have shown that curcumin increases the risk of bleeding in patients taking diluents at the same time, so any possible drug interactions or concerns must be discussed with your doctor. There have also been reports of curcumin powder causing allergic reaction to contact, such as itching or rash immediately after contact.

While most chili powder sold in US grocery stores contains blended spices, this term can also be used for powdered hot peppers on their own. This usage is common in Asian recipes and grocery stores. These powders tend to be much spicier than blended American chili powder.