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A significant body of research, mostly from rodent models and in vitro studies, has linked titanium dioxide with health risks related to the gut, including intestinal inflammation, alterations to the gut microbiota, and more. It is classified by the International Agency for Research on Cancer (IARC) in Group 2B, as possibly carcinogenic to humans.

At the present JECFA meeting, the committee considered additional toxicological studies relevant to the safety assessment of the chemical that investigated its toxicokinetics, acute toxicity, short-term toxicity, long-term toxicity and carcinogenicity, genotoxicity, and reproductive and developmental toxicity, as well as special studies addressing its short-term initiation/promotion potential for colon cancer. The experts acknowledged that a large number of toxicological studies have been conducted using test materials, including nanoparticles, having size distributions and physico-chemical properties not comparable to real-world uses of titanium dioxide as a food additive. The studies on non-representative materials were evaluated by JECFA, but the committee concluded that such studies are not relevant to the safety assessment of the additive.

Some consumer advocacy groups and health agencies — particularly, those at the Environmental Working Group — have been pushing federal officers at the Food and Drug Administration (FDA) to reconsider their existing rules on the additive, which is commonly found in processed snacks and sweets.

Thermogravimetric analysis (TGA) was conducted in a sample of vitaminB2@P25TiO₂NPs using a TA-THA Q5000 equipment. Temperature ramp rate: 10 °C/min, maximum temperature: 1000 °C, under air. Part of the same sample was mounted on conductive copper tape grids and observed through a Carl Zeiss Sigma scanning electron microscope (SEM) with an EDS probe, at the “Laboratorio de Microscopía y Análisis por Rayos X” (LAMARX) of National University of Córdoba (Argentina).

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